FIgure 2

Figure 2: To redesign the cell-pairing device for immune cells, we have established a finite element fluids model. The plot shows the predicted effect of reducing cup spacing (normalized by the downscaled immune cell device) on the relative flow rate through the capture cups. The blue line represents the original cell fusion device. The green line represents simple downscaling of the original device, yielding low flow and, presumably, pairing efficiency. The physical limit (black line) indicates the smallest cup spacing possible that still permits cells to pass between two cups. The model shows that reduc¬ing the horizontal cup spacing can increase flow through the cups and, ultimately, pairing efficiencies for immune cells.

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    Akintunde Akinwande Anantha Chandrakasan Brian Wardle Carlijn Mulder Carl Thompson Caroline Ross Charles Sodini Chih-Hao Chang CICS Clifton Fonstad Dana Weinstein Dimitri Antoniadis Duane Boning Eugene Fitzgerald Faraz Najafi Francesco Marsili George Barbastathis Hae-Seung Lee Harry Tuller Ichiro Masaki Jason Sussman Jeffrey Lang Jesus del Alamo Jing Kong Joel Dawson Joel Voldman Jongyoon Han Judy Hoyt Karen Gleason Karl Berggren Lan Wei Luca Daniel Luis Velásquez-García Marc Baldo Omar Mysore Philip Reusswig Rajeev Ram Sang-Gook Kim Sangeeta Bhatia Scott Manalis Sean Bishop Tomas Palacios Vitor Manfrinato Vladimir Bulovic Vladimir Stojanovic