Figure 1

Figure 1: Investigation of autocrine signaling using cell patterning.  A) Stencil patterning was used to organize the square-latticed arrays of circular patches.  B) Resulting cell patterns of the A431 epidermoid carcinoma cells of varying array spacing.  Scale bar, 500 µm.  C) Changes of local density (e.g., neighbor number) with alteration of global cell density in randomly plated and patterned cell arrays.