Figure 2

Figure 2: Creative cell-patterning designs.  A) Calculated fractions of ligands with autocrine trajectories for varying total patch areas and patch radii.  B) Examples of single-patch designs with varying radii, the composite-patch designs with the same total area, and the actual resulting patterns.  C) Designs of cell arrays for studying autocrine signaling contribution on cell-to-cell variability.  The right-hand plot illustrates predicted ligand concentration for both designs.