grover_density_02

Figure 2: A) Single erythrocyte mass vs. density for an individual with suspected thalassemia who also received a transfusion of normal (nonthalassemic) blood 4 days prior to collection (red; n = 502 cells) compared to a random nonthalassemic, nontransfused individual (black; n = 502 cells). The patient’s own erythrocytes (red) are offset from a normal patient’s erythrocytes (black), except for a few normal erythrocytes the thalassemic patient received during the transfusion (red points clustered on black points). B) Erythrocytes from an individual with sickle-cell anemia who also received a blood transfusion 35 days before collection (red; n = 502 cells) compared to the same nontransfused individual as in A (black; n = 502 cells). The widening distribution of erythrocyte densities in sickle cell anemia is consistent with previous studies, with denser cells likely representing irreversibly sickled cells.

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