Collaborators

• Y. Fink, DMSE, MIT
• E. Bizzi, McGovern Institute for Brain Research
• Graduate Students
• A. Canales, Research Assistant, DMSE
• R. Chen, Research Assistant, DMSE
• N. Lachenmyer, Research Assistant, EECS

Support Staff

• A. Inserto, Administrative Assistant II

Publications

Anikeeva, P., Andalman, A.S., Witten, I.B., Warden, M.R., Goshen, I., Grosenick, L., Gunaydin, L.A., Frank, L., Deisseroth, K., Optetrode: a multichannel readout for optogenetic control in freely moving mice, Nat. Neurosci. 15, 163, 2011.

Witten, I.B., Lin, S.C., Brodsky, M., Prakash, R., Diester, I., Anikeeva, P., Gradinaru, V., Ramakrishnan, C., Deisseroth, K. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science, 330, 1677, 2010.

Shirasaki, Y., Anikeeva, P.O., Tischler, J.R., Bradley, M.S., Bulović, V. Efficient Förster energy transfer from phosphorescent organic molecules to J-aggregate thin films, Chem. Phys. Lett., 485, 243, 2010.

Panzer, M.J., Aidala, K.E., Anikeeva, P.O., Halpert, J.E., Bawendi, M.G., Bulović V. Nanoscale morphology revealed at the interface between colloidal quantum dots and organic semiconductor films. Nano Lett. 10, 2421, 2010.

Anikeeva, P.O., Halpert J. E., Bawendi, M.G., Bulović, V. Optimized Materials for High Performance QD-LEDs with Electroluminescence Tunable over Entire Visible Spectrum, Nano Lett., 9, 2009.

Hummon, M.R., Stollenwerk, A.J. , Narayanamurti, V. , Anikeeva, P.O., Panzer, M.J., Wood, V.C., Bulović, V. Detecting Charging Energy and Charge State of CdSe/ZnS Quantum Dots using a Scanning Tunneling Microscope. Phys. Rev. B, 2009.

Anikeeva, P.O., Madigan, C.F., Halpert, J.E., Bawendi, M.G., Bulovic, V. Electronic and Excitonic Processes in Hybrid Organic-Quantum Dot LEDs, Phys. Rev. B 78, 2008.

Kim, L., Anikeeva, P. O., Coe-Sullivan, S. A., Steckel J. S., Bawendi, M. G., Bulović, V. Contact Printing of Quantum Dot Light Emitting Devices, Nano Lett., 8, 2008.

Anikeeva, P.O., Halpert J. E., Bawendi, M.G., Bulovic, V. Electroluminescence from a Mixed Red-Green-Blue Colloidal Quantum Dot Monolayer, Nano Lett. 7, 2196, 2007.

Anikeeva, P.O., Madigan C. F., Coe-Sullivan, S. A., Steckel, J.S., Bawendi, M.G., Bulovic, V. Photoluminescence of CdSe/ZnS core/shell quantum dots enhanced by energy transfer from a phosphorescent donor, Chem. Phys. Lett. 424, 120, 2006.

Steckel, J.S., Snee, P., Coe-Sullivan, S. A., Zimmer, J.P., Halpert, J. E., Anikeeva, P.O., Kim, L., Bulovic, V., Bawendi, M.G. Color-Saturated Green-Emitting QD-LEDs, Angew. Chem. Int. Ed. 45, 5796, 2006.

Ivanov, S.A., Nanda, J., Piryatinski, A., Achermann, M., Balet, L.P., Bezel, I. V., Anikeeva, P.O., Tretiak, S., Klimov, V. I. Light Amplification Using Inverted Core/Shell Nanocrystals: Towards Lasing in Single-Exciton Regime, J. Phys. Chem. 108, 10625, 2004.

Lack of technology for high-throughput electronic recordings and simultaneous stimulation is a major limiting factor for the development of neuroprosthetics and for understanding electrophysiological signatures of the diseased brain. For example, our inability to monitor neural activity during deep brain stimulation (DBS) in Parkinson’s disease patients limits choices for possible therapies. To enable simultaneous neural recording and stimulation, we have previously demonstrated a miniature device “optetrode,” which combines optical fiber light delivery and microelectrode neural recording in freely moving mice during neuroscientific experiments ^[1] .

This project extends the optetrode’s concept to fabrication of versatile neural recording devices (shown in Figure 1) using a novel fiber-inspired processing method. Our fabrication technique allows for extreme reduction of the active probe diameter potentially enabling intimate interfaces with individual neurons (as Figure 2 shows). Our approach allows for simultaneous processing of multiple materials (polymers and metals) and can be used for high-throughput fabrication of multiple functional elements such as neural recording and, optical stimulation. In addition, the geometry of our devices can be tailored to a particular application such as brain, spinal cord, or peripheral nerve recordings.

1. P. Anikeeva, A. S. Andalman, I. B. Witten, M. R. Warden, I. Goshen, L. Grosenick, L. A. Gunaydin, L. Frank, and K. Deisseroth, “Optetrode: A multichannel readout for optogenetic control in freely moving mice,” Nature Neuroscience, vol. 15, pp. 163-170, Dec. 2011.